US Naval Activities, (NAVACTS) London was established in 1951 by the direction of the Chief of Naval Operations as a union of two shore commands; US Naval Activities in London, and US Naval Facility, London. The functions assigned these two commands had been previously performed by the Headquarters Command, Commander in Chief, Eastern Atlantic and Mediterranean (CINCNELM). Personnel assigned upon this establishment were largely drawn from the CINCNELM staff.

In 1958, the US Naval Facility, London was designated as the US Naval Support Activity, London. As other Naval activities in the United Kingdom and Northwestern Europe were established, the command was designated by the Secretary of the Navy to its present title of US Naval Activities, United Kingdom (NAVACTUK). In August 1965, the US Naval Support Activities, London was disestablished and reassigned to COMNAVACTUK, consolidating the support activity and old facility into one command.

CNAUK was disbanded on 14 September 2007 at RAF Daws Hill.

Support tenant activities and U.S. Government perosnnel in Greater London. Exercising command over subordinate activities. Serve as regional area coordinator for U.S. Naval Activities and deployed units in the U.K., gibraltar, and Nortern Europe.

The mission of Navy Region Europe is to provide effective and efficient shore services to U.S. and allied forces within the European theater supporting operations in Europe and Africa. Commander, Navy Region Europe is responsible for the management of six Navy shore installations within the European theater including Joint Maritime Facility St. Mawgan, England; Naval Support Activity La Maddalena, Italy; Naval Support Activity Naples, Italy; Naval Station Rota, Spain; Naval Air Station Sigonella, Sicily, Italy, and Naval Support Activity Souda Bay, Crete, Greece.